kidney stone surgical procedures - New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
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New Gout Drugs ??? Pegloticase Continues Its Hopeful Path

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.


Medications should be taken within a short while of the onset; otherwise the attack may get beyond control. If no treatment is administered within the first 12 hours, combating gout becomes near to impossible. If you are a frequent sufferer, do remember to carry necessary medicines wit you wherever you go, even on business or pleasure trips. Do take sufficient rest until the attack completely subsides, overuse of the strained joints may cause irreparable damage. For more tips and info about Gout?, feel free to visit us at: http://www.about-goat.info


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 Gout is a form of arthritis caused by high levels of uric acid in the blood, tissues, and urine. The uric acid can form crystals which collect in joints such as the big toe. In fact, your big toe can become so painful and swollen that even the weight of a bedsheet can be agonizing.

Losing excess weight may also reduce uric acid levels, but it must be done gradually and under a doctor's supervision. Severe dieting or fasting can actually make your gout worse.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

It's best to eat the cherries or drink the cherry juice between meals. So why do cherries work for some people with gout? Because gout destroys the collagen that is needed to form connective tissue and cherries stop that destruction. Cherries also neutralize uric acid and have anti-inflammatory properties.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

Important Disclaimer: This information is presented for educational purposes only. This isn't medical advice and it's not a substitute for any advice or treatment from your physician. You should always see your doctor before starting any new diet plan for losing weight or controlling gout.

There are some lucky gout patients that only suffer from a gout attack once in their lives. However, for the majority of the gout patients, those flares will return. If you do not treat the gout attacks when they happen, as time passes by, they will become more and more severe and last even longer than the previous gout flares.

You should always consult a doctor for treatment of gout. But some of the drugs used for gout - such as allopurinol, colchicine, indomethacin, and prednisone - can cause serious side effects.

Purine is a normal constituent of the human diet. It is metabolized within the body to produce uric acid, which then reacts with the sodium ions present in the system to give mono-sodium urate (MSU). The production of MSU rises with the internal pH of the body. At the biological pH, the MSU exists in the form of insoluble crystals that deposit on the joints of the body. The bodys defense mechanism recognizes these accumulated crystals as foreign invasions and combats them with white blood cells called neutrophils. As a result of this immunologic reaction, sudden inflammation and rubor of the skin develops, along with heat production and tenderness of the affected regions. This is accompanied by excruciating pain as the bodys defense mechanism fights the invading MSU crystals. The symptoms include malaise, fever, chills, increased heart rate, and high blood pressure.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Many people also try to eliminate foods with high purine levels from their diets. Some of these foods may worsen gout by increasing your level of uric acid.

Almost 90% of gout victims are men over thirty years old. But women can also suffer from gout, especially if they take certain medications such as blood pressure drugs. Most women who suffer from gout are 60 years or older.

Uric acid is highly tied to gout, because the excess of this acid in your blood is actually the cause of a gout. Little crystals form as a result, they collect in the joints and cause pain and inflammation. This is gout at the beginning. The breakdown of chemicals called purines is what uric acid is made from. These chemicals can be found in different foods and alcohol. So if you suffer from gout or if you try to prevent a gout case from happening to you, try to avoid those things as much as possible.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

Diagnosing gout is not very complicated. If having any gout signs go see your doctor.He/ she will do a blood test to see what are your uric acid levels. If there is still doubt, some fluid is then taken from your joints and checked for crystals. Then, based on the results, you can be diagnosed with gout or not.

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

Because nothing is simple in medicine and life, irony strikes in gout case as well. There are people who have risen uric acid levels, but never actually have to deal with gout and there are others that have gout despite the fact that their levels of uric acid are normal.

 
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Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

Red and black cherries - fresh, frozen or canned - have been used successfully to treat gout. Drinking several tablespoons of black cherry juice daily may produce the same effect.

This particular arthritis type manifests itself through sudden, painful attacks. Gout attacks develop very quickly, in a few hours time, and can last as long as three to four days, if they are untreated. Severe pain, redness, inflammation and swollen joints are the main symptoms of a gout flare, that mostly affects the joint of the big toe. Other joints can be affected by a gout attack as well. Your hand, foot, ankle and knee joints can be affected by these gout flares.

Gout attacks typically set in between midnight and 2 a.m. and are more frequent during the spring. The initial attacks may wane automatically within a few days even without treatment, as the crystals become encrusted by certain proteins that prevent their recognition by the immune system as non-self particles. However, gout may resurface even after years, and in due course of time the frequency of the attacks gradually increases. Ultimately, the problem becomes a persistent one and in chronic cases, can cause permanent distortion of the affected joints.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

If gout isn't properly controlled, it can cause kidney stones and even more serious kidney disease. Gout is also associated with high blood pressure, diabetes, and atherosclerosis.

There are other changes you can make to your diet, too. For example, eating a cup of strawberries may help to control gout. You should also drink plenty of water to help flush the uric acid out of your body. Six to eight 8-ounce glasses a day is probably best.

So you may want to discuss with your doctor if an alternative approach might work for you. An approach without the toxic side effects of gout drugs. One dietary approach is simply to eat cherries. In the 1950s, Dr. Ludwig Blau discovered that he could keep his gout away by eating a minimum of 6 cherries a day. It helped his crippling gout so much that he was actually able to get out of his wheelchair and start walking again.

Some high-purine foods are meats, especially organ meats, gravies, herring, mussels, sardines, fish, and alcohol. At least one study suggests that high-purine foods such as beans, peas, mushrooms, spinach and cauliflower do not make gout worse. But you should consult your doctor for the latest information and recommendations.

Gout is an extremely painful disease and can cause immense discomfort apart from complications like kidney stones and the like. Unfortunately, there is no established cure for gout. The best means of thwarting gout attacks is prevention. These insidious attacks occur when you will be least expecting it, sometimes while you are asleep.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

He discovered his "cherry cure" by accident. One day, he ate a large bowl of cherries and the next day, his foot pain was gone. He found that as long as he ate the cherries every day, his gout was controlled.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

Gout is another from of arthritis, which is known to case sudden attacks. The gout causes are known, but unfortunately this condition can not be cured. Treatments only help in reducing the severity of the gout symptoms and to prevent, as much as possible, further gout flares.

Many other people - some of whom have written to Prevention magazine - have also found relief by adding cherries to their diets. Supposedly, if you already have crippling gout or if you feel a gout attack coming on, you should eat 15 to 30 cherries a day at first to get your gout under control, then 6 to 10 cherries a day after that to keep the gout away.

HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

The most commonly afflicted areas of gout include the big toes and the joints in feet, ankles, knees, hands, wrists, arms, elbows, and bursas, the ligaments and tendons around these joints; and, in extreme cases, shoulders, necks, hips and spine.

If you are intersted in finding more information about gout you can click on this website http://www.gout-info-center.com. Also you will find there valuable information about gout diet and Foods That Cause Gout.


 
 
     
 
 





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